Palmetto Goodwill in Orangeburg, SC, is a highly recommended thrift shop known for its great clothing selection. Customers appreciate the variety of styles and sizes available, especially in the men's section, though some note it can be limited. The store is clean with minimal trash, making for a pleasant shopping experience. While housewares may not have the best selection, shoppers often find great items at good prices. Many also enjoy donating items here, contributing to the community.